Using 3D Holograms to Treat Cardiac Arrhythmia

Summary

One in 18 people (5 percent of the U.S. population) experience cardiac arrhythmia, a problem with the rate or rhythm of the heartbeat.¹ Arrhythmias can lead to complications such as stroke, fainting and death. Treatments include medicine, lifestyle changes, and a procedure called a catheter ablation. Catheter ablation uses radiofrequency heat energy to destroy a small area of heart tissue that is causing rapid and irregular heartbeats.² Typically, the physician has to mentally combine two 2D images of the heart displayed on different monitors to decide whether to remove tissue. This can cause a lot of mental fatigue.³

Husband and wife team Dr. Jonathan Silva and Dr. Jennifer Silva, MD, at Washington University in St. Louis, created the Enhanced Electrophysiology Visualization and Interaction System (ĒLVIS) to help physicians better visualize the interior of the heart during ablation procedures. ĒLVIS combines augmented reality (AR) software with Microsoft’s HoloLens headset to convert commercially available electroanatomic and catheter data into a 3D holographic image of the patient’s heart with real-time catheter locations. The physician uses their gaze and gestures to control the headset—optimizing their visualization and improving their accuracy—all while keeping their hands sterile for the procedure. And unlike virtual reality, the physician can still view their environment while the image “floats” over the patient.⁴

Significance

Cardiac ablation procedures require the physician to ablate very small areas of heart tissue (typically about 6 mm in size) while not damaging the rest of the heart muscle.⁵ The more intuitive 3D ĒLVIS display increases physician accuracy at removing tissue in the target area when compared to traditional 2D visualization, which is likely to improve patient outcomes and decrease the need for repeat procedures.⁵ ĒLVIS can also be used by multiple physicians using multiple headsets, improving coordination and supporting training.

Benefits

Demonstrated benefits are those that have been observed and are verifiable.

Potential benefits are those logically expected with moderate to high confidence.

Developed CommandEP augmented reality (AR) software that creates a 3D digital image of the interior of the patient’s heart and can be displayed using Microsoft’s HoloLens headset. demonstrated.

Clinical

Software technologies

Improved accuracy of cardiac ablation procedures by providing a real-time, 3D holographic image of the patient’s heart to help physician analyze heart tissue. demonstrated.

Clinical

Therapeutic procedures

Decrease need for repeat cardiac ablation procedures. potential.

Community

Health care quality

Founded SentiAR, a start-up company to market and sell ĒLVIS throughout the U.S. demonstrated.

Economic

Non-profit or commercial entities

Patented the ĒLVIS system and method for creating a 3D holographic image of the patient’s heart (U.S. Patent No: US10258426B2, April 2019.)⁶ demonstrated.

Economic

Patents

Reduced cardiac ablation procedure time by 30 minutes, freeing up hospital operating rooms for an additional 1-2 procedures per day, and may also reduce the need for the mapping technician role, generating additional cost savings for the hospital.⁷ potential.

Economic

Cost effectiveness

Decreased need for repeat cardiac ablation procedures would save insurers an estimated $1,224 per procedure.⁷ potential.

Economic

Cost savings

Decreased need for repeat cardiac ablation procedures would save roughly $370 million per year, with the potential for savings to increase as the population ages and more people need cardiac ablation procedures.⁷ potential.

Economic

Societal & financial cost of illness

This research has clinical, community, and economic implications. The framework for these implications was derived from the Translational Science Benefits Model created by the Institute of Clinical & Translational Sciences at Washington University in St. Louis.⁸

Clinical

ĒLVIS combines an augmented reality (AR) platform with wearable headset technology to improve the accuracy of therapeutic cardiac ablation procedures to treat irregular heart rhythms. The proprietary software technology transforms electroanatomic and real-time catheter location information into a 3D holographic image of the heart that can be manipulated by physicians through their gaze and gestures without damaging the sterile field. Tests of the ĒLVIS display in humans found adequate performance, image quality, and usability of the software for ablation procedures.⁹

Community

ĒLVIS improves health care quality by enhancing the ability of physicians to visualize damaged cardiac tissue during ablation procedures, decreasing mental fatigue, and improving accuracy. ĒLVIS can significantly reduce the number of lesions that remain outside the target area from 36% in a typical ablation to just 4%.⁵ This improved accuracy is likely to reduce the need for repeat procedures. Patients with repeat ablations are more likely to visit the emergency department and require subsequent hospitalization.¹⁰

Economic

Drs. Jonathan and Jennifer Silva co-founded SentiAR, a startup company to develop and manufacture an augmented reality (AR) platform to transform patient and clinician experiences in interventional procedures. To develop the platform, the doctors secured a patent for the system and method used to integrate the AR data with the HoloLens headset. In September 2020, SentiAR received FDA clearance to market and distribute the platform to hospitals. By reducing the average procedure length and need for specialized the staff, ĒLVIS has the potential to be cost-effective for hospitals. By reducing the need for repeat procedures, the system could save insurers an estimated $1,224 per procedure, for a savings of $370 million annually.⁷